21c Museum Hotel Louisville

Recognized as 2026 Condé Nast Traveler’s Triple Crown Award winner, 21c Museum Hotel is more than just a place to spend the night – it's a 91-room hotel, contemporary art museum, award-winning restaurant and cultural civic center nestled in the heart of Museum Row in historic downtown Louisville. With over 9000 square feet of art-filled meeting and event space, 21c guests enjoy authentic Southern hospitality and accessible luxury while exploring the work of contemporary artists in America's only museum dedicated solely to art of the 21st Century. Whether you are touring Bourbon Country, gathering with colleagues, or hosting a lavish Southern wedding, 21c is a modern epicenter for culture, activity, and artistic expression. Applauded by Travel & Leisure Magazine as "one of the most ambitious unions of art and hospitality ever undertaken," and hailed by The New York Times as "an innovative concept with strong execution and prompt and enthusiastic service," come meet the infamous Red Penguins and discover how 21c Museum Hotel is redefining the art of hospitality.